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Beamtime on the 19-ID and 19-BM beamlines is available to the research community via a peer reviewed proposal system. SBC receives support from the U. S. Department of Energy, Office of Biological and Environmental Research.

Please note New Policy on User Badges:

The security force will be scanning all user badges and visitor gate passes upon entry to the laboratory. This is being done to enhance Argonne's emergency preparedness and will provide a more accurate accounting of the people on site in the event of an emergency. Users can help prevent delays at the gates by having their badges ready to scan.

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Important Information for Non-U.S. Citizens
Tips & Information

APS PDB Depositions from BioSynch
 SBC Current Beamline Statistics

SBC
Sector
19

2013
2014
2015
Total
ID
BM
ID
BM
ID
BM
ID & BM
PDB Deposits:
238
49
228
30
24
5
4430
87
21
68
14
18
5
1562
 

actor robot available for use on 19-ID9ID

Remote Data Collection on 19-ID for experienced users

A fully motorized Mini-beam device for use on 19-ID

•19-BM upgraded and available for immediate beamtime  

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STUDY REVEALS HOW EBOLA BLOCKS IMMUNE SYSTEM

 

APS/APCF Symposium & MCSG 14th Annual Meeting The symposium reviewed the achievements of X-ray macromolecular crystallography and the future structural biology opportunities in biomedical and biological sciences. We assessed the progress on understanding structures of proteins and their families and will contemplate the future impact of new free electron laser light sources on biology and chemistry. The potential contribution and impact of Advanced Photon Source upgrade and new protein research facilities were discussed in the context of future advances in structural and molecular biology. Thank you to those who attended. 

Newly ID'd protein provides tArget for antibiotic-resistant hospital bacterium

 

STRUCTURAL BIOLOGY REVEALS THE SECRETS OF DISEASES

 

 

 

 

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Gallary of Journal Covers

 

The SBC is dedicated to performing scientific research in a safe and environmentally sound manner. No job or experiment at the SBC is given authorization to proceed without first performing a review of the hazards involved and the controls to be implemented regardless of beamtime scheduling and/or cost impacts.
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An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions

Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, Amarasinghe GK., Cell Rep. 2015 Apr 21;11(3):376-89.

During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA-template-bound form and a template-free form to provide the viral polymerase access to the RNA template. In addition, newly synthesized NP must be prevented from indiscriminately binding to noncognate RNAs. Here, we investigate the molecular bases for these critical processes. We identify an intrinsically disordered peptide derived from EBOV VP35 (NPBP, residues 20–48) that binds NP with high affinity and specificity, inhibits NP oligomerization, and releases RNA from NP-RNA complexes in vitro. The structure of the NPBP/ΔNPNTD complex, solved to 3.7 Å resolution, reveals how NPBP peptide occludes a large surface area that is important for NP-NP and NP-RNA interactions and for viral RNA synthesis. Together, our results identify a highly conserved viral interface that is important for EBOV replication and can be targeted for therapeutic development.

 



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