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Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex





Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation



DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants



Resistance to Enediyne Antitumor Antibiotics by Sequestration



Activator Protein-1: redox switch controlling structure and DNA-binding





Activator Protein-1: redox switch controlling structure and DNA-binding



Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor.



Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events






Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.


A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.


The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture.


Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.


Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.


A novel signal transduction protein: Combination of solute binding and tandem PAS-like sensor domains in one polypeptide chains.


Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.


Inhibition of RAS function through targeting an allosteric regulatory site.


Structural Basis for Ligand Binding to the Guanidine-I Riboswitchs.



NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.


Bile salt receptor complex activates a pathogenic type III secretion system.


Crystal Structure of the FERM-SH2 Module of Human Jak2.


Structural Studies of Medicago truncatula Histidinol Phosphate Phosphatase from Inositol Monophosphatase Superfamily Reveal Details of Penultimate Step of Histidine Biosynthesis in Plant.


Crystal structure of the human sterol transporter ABCG5/ABCG8.


Structural basis of cohesin cleavage by separase.


Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana.


Structural and molecular basis for Ebola virus neutralization by protective human antibodies.



A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria


Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2


A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism


EsxB, a secreted protein from Bacillus anthracis forms two distinct helical bundles


Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae


An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions


Crystal structures of alkylperoxo and anhydride intermediates in an intradiol ring-cleaving dioxygenase



Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.


Structure of a symmetric photosynthetic reaction center-photosystem.


A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.


The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily.


Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.


A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35−NP Interface.


Structure of the active form of human origin recognition complex and its ATPase motor module.


Non-classical transpeptidases yield insight into new antibacterials.




Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.


Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase.


Phosphorylation of spore coat proteins by a family of atypical protein kinases.


The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA.


The Vaccinia Virus H3 Envelope Protein, a Major Target of Neutralizing Antibodies, Exhibits a Glycosyltransferase Fold and Binds UDP-Glucose.


Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.


Molecular mechanism of respiratory syncytial virus fusion inhibitors.



Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892


Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion


Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form


Structural integration in hypoxia-inducible factors


New aminopeptidase from microbial dark matter archaeon


A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity


Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phos. STAT1